Incidence Of Non-communicable Diseases Research Articles

Obesity, beverage consumption and sleep patterns in rural African women in relation to advertising of these beverages.

The burden of obesity-related, non-communicable diseases in South Africa is persistent, with poor and black South African women particularly vulnerable. The purpose of the present study was to determine relationships between obesity, physical activity, sleep patterns and beverage consumption among black South African women in a rural village in the Limpopo province. A cross-sectional study was conducted among 200 rural-dwelling African women. Data were collected on beverage consumption, sociodemographic information, sleep patterns and anthropometry using self-reported questionnaires. The mean body mass index (BMI) was 28.5±7.3kg/m2, with 40% being classified as obese (BMI ≥30kg/m2) and the mean sleep score was 4.68±2.51. Participants with very bad habitual sleeping patterns consumed significantly more sugar-sweetened beverages and alcohol than those with very good sleeping patterns. We also observed that when total coffee with sugar, fruit juice, total sugar-sweetened beverages and weight decreased the number of hours participants slept increased. The study identified significant associations between body weight, sleep duration and sugar-sweetened beverage consumption among rural black South African women. This underscores a need to address unhealthy lifestyle behaviours to lower incidences of non-communicable diseases in rural-dwelling women.

Atlas 2022 of African health Statistics: Key results towards achieving the health-related SDGs targets

IntroductionThe Atlas 2022 of African Health Statistics is a comprehensive tool that gives an overview of the health ecosystem in the African region. As such, it tracks progress towards globally agreed objectives, such as Sustainable Development Goals (SDGs), assesses the capacity of African countries to achieve them, and helps policymakers identify gaps and areas requiring substantial reinforcement. MethodsWe analyzed health-related SDGs’ key indicators in the Atlas 2022 of African Health Statistics. This platform is a nexus for consistent and comparable data sources across countries. A review of studies addressing the evolution of health-related SDG indicators in Africa was also considered for discussion and recommendations. ResultsHunger and different forms of malnutrition remain prevalent in the Region. Maternal and neonatal mortality is still high compared to other regions, with increasing incidences of non-communicable diseases and poor mechanisms to address mental health issues. Many inequalities are noted in violence against women, access to health services, or access to water and basic sanitation, which is exacerbated in rural areas. Regarding achieving the SDGs, the trend of most indicators shows they will be challenging to perform at the Regional level. However, a few countries are on track to achieve some goals. These results clearly show that countries have different experiences and, therefore, different progress in achieving sustainable development goals. The delays experienced by many countries in terms of development in other sectors, such as climate and the environment, poverty reduction and economic growth, equity and justice, etc., will make it even more difficult to achieve the health-related SDGs. Achieving these goals should, therefore, be seen as a transdisciplinary and inclusive process. ConclusionBeyond the COVID-19 pandemic that has recently challenged health systems worldwide, the African Region is also dealing with several threats, jeopardizing its progress toward achieving the SDGs by 2030. Given the Region’s particular context, a readjustment of the regional targets and/or deadlines would be advisable to ensure they are achievable.

Promotive and preventive education of non-communicable diseases for the community

Non-communicable diseases such as diabetes, cancer, and heart disease are global health challenges that require a holistic approach to their prevention and management. Promotive and preventive education has been recognized as an effective strategy for increasing public health awareness and reducing the incidence of non-communicable diseases. This service activity can improve health awareness in the community, primarily related to promotive and preventive education. Measures such as education campaigns, education in schools, collaboration with communities, and the use of technology have been discussed as effective strategies for achieving this goal. In conclusion, the joint efforts of different parties and diverse methods are crucial to creating an environment that supports high health awareness. Implementing the right strategy is expected to increase public understanding of the importance of a healthy lifestyle and the prevention of non-communicable diseases and produce positive behavioral change in the long term. Joint efforts from different sectors and diverse methods can help increase health awareness in the community, realize a healthy lifestyle, and reduce the risk of non-communicable diseases significantly. Health awareness includes an understanding of a healthy lifestyle and the ability to implement that knowledge in everyday life.

Initiation of Gerai Tensi for screening and prevention of non-communicable diseases in the community

Background: The increased incidence of non-communicable diseases (NCDs) necessitates continuous promotional and preventive activities to reduce morbidity and mortality. Since NCDs cannot spread like infectious diseases, they are frequently neglected. In addition, NCDs represent a significant health burden as they can develop chronic consequences and lead to fatalities. The growing burden of NCDs is attributed to increased risk factors, including elevated blood pressure, obesity, body mass index, and blood sugar levels. Furthermore, NCDs can be the primary factor in long-term decreased productivity, leading to detrimental effects on social and economic resources. Some NCDs that are receiving the most attention and have the highest prevalence are hypertension and obesity. This paper aimed to present the prevalence of hypertension and obesity in a village community. Methods: We hosted a Gerai Tensi program as one of the community-based attempts to identify and screen for NCDs. This program was conducted in Dukuh Gowongan RT 003/ RW 002, Pucangan Village, Kartasura District, Sukoharjo Regency, Central Java Province, Indonesia. All the residents aged ≥15 years old were invited to attend Gerai Tensi. The participant's blood pressure, height, weight, and waist circumference were measured. Results: A total of 75 residents of Dukuh Gowongan attended Gerai Tensi. Most participants were female (53.3%), aged 46–55 (24.0%). There were 54.7% (41/75) of participants with hypertension, mainly classified as stage I hypertension (31/75; 41.3%), and 58.7% (44/75) of participants who were obese, mostly grade I obesity (28/75; 37.3%). Conclusion: Hypertension and obesity are prevalent in the community, reaching more than half of the study participants. Coordination with the community health centre and village representatives is required to optimize the promotion and prevention activities, the treatment of diseases, and the sustainability of the Gerai Tensi program.

Effects of Dietary Restriction on PGC-1α Regulation in the Development of Age-associated Diseases.

Ageing is the most significant risk factor for a number of non-communicable diseases, manifesting as cognitive, metabolic, and cardiovascular diseases. Although multifactorial, mitochondrial dysfunction and oxidative stress have been proposed to be the driving forces of ageing. Peroxisome proliferator-activated receptor γ coactivator α (PGC-1α) is a transcriptional coactivator central to various metabolic functions, of which mitochondrial biogenesis is the most prominent function. Inducible by various stimuli, including nutrient limitations, PGC-1α is a molecule of interest in the maintenance of mitochondrial function and, therefore, the prevention of degenerative diseases. This review involves a literature search for articles retrieved from PubMed using PGC-1α, ageing, and dietary restriction as keywords. Dietary restriction has been shown to promote tissue-specific PGC-1α expression. Both dietary restriction and PGC-1α upregulation have been shown to prolong the lifespans of both lower and higher-level organisms; the incidence of non-communicable diseases also decreased in fasting mammals. In conclusion, dietary interventions may delay ageing by regulating healthy mitochondria in various organs, presenting the possibility of a new primary prevention for many age-related diseases.

Diabetes mellitus and associated risk factors among HIV infected patients on HAART

BackgroundUnderstanding the impact of disease associations is becoming a priority in Kenya and other countries bearing the load of infectious diseases. With the increased incidences of non-communicable diseases and the endemicity of infectious diseases in Sub-Saharan Africa, their co-existence poses significant challenges to patients, health workers and an overwhelmed health sector. Classical risk factors for diabetes such as physical inactivity and unhealthy diet may not solely explain the current trends, suggesting the role of novel risk factors including infections/inflammation. HIV and its treatment have been identified as potential contributors especially to patients with family history of confirmed diabetes cases. Co-infections frequently observed during HIV infection also significantly influence both the epidemiological and pathophysiological of the link between HIV and diabetes. Understanding the correlates of HIV and diabetes is crucial to inform management and prevention strategies of the twin infections. We therefore aimed to determine the prevalence of diabetes mellitus and risk factors in a population of HIV infected patients on HAART. This study determined the association of diabetes/impaired glucose regulation in the context of HIV-1. A cross-sectional study was conducted at a comprehensive care clinic in Nairobi (Kenya). Participants were screened for diabetes and impaired glucose regulation using random blood glucose and glycated haemoglobin (HbA1c) This paper describes the prevalence of diabetes mellitus in Human Immunodeficiency Virus positive individuals and the associated risk factors. We have demonstrated that family history is a risk factor for diabetes. While age and BMI are known risk factors, they were not associated with diabetes in this study.

Prevalence and determinants of overweight and obesity among adolescent school children of Rajkot city, India

Adolescent obesity is becoming more prevalent due to changing lifestyles, and it has negative effects like a higher incidence of non-communicable diseases. Identification of risk factors leading to the rapid rise in adolescent obesity is a crucial first step in preventing and controlling it. Therefore, this study was carried out in Rajkot. The primary objective was to find the prevalence of obesity among the school going adolescents aged 14-19 years and to identify the determinants associated with obesity. A cross-sectional study among the adolescents studying in school was carried out by using multistage sampling method. A predesigned questionnaire with personal and family history and details of dietary habits and physical activity was filled by the participants. Anthropometric measurements of the participants including height, weight, waist and hip circumference were taken. Out of total 1120 participants, 25.8% were underweight, 11.1% were overweight and 6.9% were obese. Overweight and obesity was significantly associated with the occupation of participant’s father and mother, lack of physical activity, more screen time, non-vegetarian diet and daily consumption of carbonated drinks and chocolates. (p<0.001). The determinants like physical activity and dietary habits were found to be associated with overweight and obesity. Modifying one's lifestyle can be very helpful in preventing adolescent obesity as well as developing healthy routines for later life.

Public expenditure on health care and the incidence of non-communicable diseases (NCDs) in China from 2008 to 2018

ObjectivesThis study investigates whether differences in individual-level and provincial-level health funding could explain or mitigate health inequalities among older people in terms of non-communicable diseases within a population served by fragmented health insurance schemes. Study designA national repeated cross-sectional analysis was done of the 2008, 2011, 2014, and 2018 Chinese Longitudinal Healthy Longevity Surveys. These provided a total of 44,623 persons aged 60 and over. Main outcome measuresRespondents were asked whether they had been diagnosed with any types of non-communicable diseases by doctors. A dichotomous outcome variable was constructed to indicate whether older people had any diagnosed non-communicable diseases. ResultsCompared with uninsured older persons, those who were enrolled in social health insurance schemes designed for civil servants as cadres, urban employees and urban residents were more likely to report a higher incidence of non-communicable diseases. There were no significant differences in the prevalence of non-communicable diseases between uninsured older people and those in the New Rural Cooperative Medical Scheme. Although the incidence of non-communicable diseases among older persons increased over the study period, greater health expenditure was significantly associated with a lower risk of non-communicable diseases. The interaction results between individual social health insurance schemes and public health expenditure indicate that disparities in the incidence of non-communicable diseases among different health insurance schemes diminish as public health expenditure increases. Older individuals with Public Free Medical Services benefited the most in provinces with higher public health expenditure compared with other health insurance schemes. ConclusionsGiven the evidence of the beneficial effects of universal health coverage on non-communicable diseases among older persons, these results should encourage policy makers to increase public health funding and to raise the overall benefit packages for social health insurance schemes.

Nutritional interventions in prison settings: a scoping review.

Mounting evidence has shown that incarceration can affect the health and well-being of individuals and increase the risk of noncommunicable diseases (NCDs). Diet quality is known to be one of the main determinants of risk of NCDs, and dietary changes are the first approach used in primary care to reduce the incidence of NCDs. This scoping review aimed to summarize the evidence for (1) the diet quality of inmates, and (2) the effect of nutritional intervention in prison systems. In addition, we aimed to describe limitations in the current literature and to suggest potential future research areas. A systematic search was performed in 2 databases (PubMed and Web of Science) using predefined search terms and covering the period May 2023 to June 2023. Additionally, reference lists from the retrieved studies were hand-searched to identify any additional relevant publications. The identified literature was screened based on defined search strategies, criteria, and research questions defined using the PICo (population or problem, interest, and context) framework. The review was conducted referring to the PRISMA-ScR and the PICo framework. A total of 19 studies out of 63 initially identified records were included in this review (11 cross-sectional evaluations and 9 intervention-based studies). In almost all studies, assessment of the diet quality of menus showed the menus to be nutritionally adequate, except for having a higher-than-recommended intake of total energy, saturated fatty acids, sodium, cholesterol, and sugar. In addition, some studies reported a lower-than-recommended intake of fiber, magnesium, potassium, vitamins D, E, and A, and omega-3 fatty acids. Nutritional interventions were mainly planned in the form of workshops, seminars, and written material to deliver information on healthy dietary choices. Although no significant changes in inmates' dietary choices were observed in any of the studies, a high participation rate was detected. Inmates might require additional prevention intervention to reduce their susceptibility to cardiometabolic diseases by virtue of their isolation from community facilities. Interventions should be tailored to the characteristics of prison settings and inmates to increase adherence to nutritional recommendations.

Hypoxic, blood flow restriction, or eccentric cycling: Which training intervention is the most effective in elderly individuals?

Introduction
 The global rise in the elderly population is accompanied by an increased incidence of non-communicable diseases, including cancers, cardiovascular conditions, or sarcopenia. Therefore, it becomes crucial to find effective strategies to delay the onset or slow down the progression of these diseases. Hypoxic (HYP), blood flow restriction (BFR), and eccentric (ECC) training are promising modalities to mitigate the effects of aging. However, these training strategies have never been compared. Thus, this study aimed to evaluate whether moderate-intensity intermittent training (MIIT) combined with HYP, BFR, or ECC can induce similar or greater effects in strength and muscle mass in the elderly, compared to traditional cycling training (CON).
 Methods
 Fifty-five elderly participants completed a four-week MIIT protocol on cycle ergometers, divided into HYP, BFR, ECC, and CON groups. The HYP group trained under hypoxic conditions (inspired oxygen fraction ~14%), BFR group used occlusion cuffs applied proximally on thighs (~350 mmHg occlusion pressure), ECC group trained with an eccentric cycle-ergometer, and the CON group underwent standard cycling training. The first week consisted of 3 sets of 5 min exercise followed by 5 min rest and an additional set was added each week. All groups maintained a 60-rpm cadence, with intensity set at a 14-perceived exertion level on the 6-20 Borg scale.
 Strength parameters were assessed via isokinetic tests at angular velocities of 30°/s, 90°/s, and 180°/s, as well as isometric and endurance tests. Endurance strength was calculated as a percentage decrement score during 30 repetitions at 180°/s and the rate of force development was calculated on the isometric test.
 Muscle-bone cross-sectional area (CSA) was measured by integrating thigh circumference measured using a measuring tape, and anterior and posterior adipose tissue thickness assessed with a B-mode ultrasound.
 Results
 Post-training, all groups showed increased isometric quadriceps strength (14 ± 15%, p < 0.001) and strength at all angular velocities: 18 ± 17% and 15 ± 21% (30°/s), 17 ± 20% and 20 ± 26% (90°/s), 10 ± 14% and 10 ± 16% (180°/s) for quadriceps and hamstrings respectively, all P < 0.001. No significant group interaction effects were noted, except for hamstring strength at 30°/s (P = 0.038), with no improvements in the ECC group. No changes in the rate of force development or dynamic endurance post-training were noted. Thigh circumference increased (1 ± 2%, p = 0.008), without difference between training modalities.
 No significant variations in adipose tissue thickness or muscle-bone CSA occurred. The ECC group had higher training intensity (173.2 ± 7.5 W) than HYP (169.6 ± 9.8 W), BFR (169.9 ± 11.6 W), and CON (169.6 ± 8.4 W) groups (p < 0.001). Training heart rate was lower in ECC (104.5 ± 6.6 bpm) compared to BFR (117.5 ± 10.5 bpm; p = 0.007) and CON (122.2 ± 12.3 bpm; p = 0.001), but similar to HYP (112.2 ± 9.4 bpm).
 Discussion/Conclusion
 MIIT, regardless of modality, effectively improves muscle strength in the elderly. Unexpectedly, no single training method was superior. Power output reduction has been proposed as an advantage of HYP and BFR modalities but was not observed in the present study. These results advocate for a personalized approach to training prescriptions, considering individual preferences and health conditions. Future research should explore longer training durations and impacts on other health outcomes such as cardiovascular and respiratory health.

Kharameh cohort study (KHCS) on non-communicable diseases and preliminary findings of 3-year follow-up

PurposeThe Kharameh cohort study (KHCS) is one branch of the ‘Prospective Epidemiological Research Studies in Iran’, located in the south of Iran. The enrolment phase of KHCS spanned from April...

Perilaku Sedentary pada Remaja Akhir Berdasarkan Banyaknya Akun Media Sosial yang Dimiliki

Non-communicable diseases including cardiovascular disease, diabetes and cancer are the number 1 killers in the world. According to the Indonesian Ministry of Health, the incidence of non-communicable diseases in Indonesia increase every year. One of the main factors causing non-communicable diseases is sedentary lifestyle. Sedentary lifestyle are activities that all types of activities need very little caloric (< 1.5 METs). Currently, the use of social media among adolescents is massive. This study aims to identify sedentary behavior in late adolescents based on the amount of social media they have. This research was a correlational analytical research with a cross sectional approach. The sample were 193 students of the Faculty of Health in Kediri. The data were collected using snowball sampling. The instrument used in this study was a modified Sedentary Behaviour Questionary (SBQ). The data obtained were analyzed using the Spearman Rank Test. The results of this study showed that 49.7% performed high sedentary behavior. 42% of late adolescences have 4/more social media accounts, 90.7% of late adolescences use social media daily. The results of the Spearman rank test obtained p-value: 0.031 so there was a relationship between the amount of social media and sedentary behavior, and also p-value: 0.036, Correlation Coefficient: 0.615 so that there was a strong relationship between frequent use of social media with sedentary behavior. From the results of the study, it is recommended to reduce the intensity of social media, so that sedentary behavior can also be minimized, and prevent non-communicable diseases.

EDUKASI DIIT YANG TEPAT UNTUK PENGENDALIAN PENYAKIT TIDAK MENULAR PADA LANSIA DI DESA NARMADA LOMBOK BARAT

Non-communicable diseases (NCDs) are currently the biggest cause of death. According to WHO, NCDs are the leading cause of death in the world, where in 2016 as many as 71% of deaths were caused by non-communicable diseases. Based on the type of disease causes of death include cardiovascular disease (31%), cancer (16%), chronic respiratory disease (7%) and diabetes mellitus (3%).WHO data also shows that the mortality rate due to non-communicable diseases in the Southeast Asian region is quite high, which is around 23% when compared to European countries (17%) and America (15%), proper control of diit can reduce the incidence of NCDs. Method: This method of community service is carried out in the form of providing education about the right diit for non-communicable disease control by means of lectures and distributing leflets followed by questions and answers and discussion. Conclusion: from the results of the service, it can be concluded that the education provided can increase public knowledge about non-communicable diseases, so that the community is expected to be able to prevent and handle NCDs themselves with the right diit arrangements

Estimating the potential impact of a health tax on the demand for unhealthy food and beverages and on tax revenue in India.

Foods high in fat, sugar or salt are important contributors to the rising burden of non-communicable diseases globally and in India. Health taxes (HTs) have been used by over 70 countries as an effective tool for reducing consumption of sugar sweetened beverages (SSBs). However, the potential impacts of HTs on consumption and on revenues have not been estimated in India. This paper aims to estimate the potential impact of health taxes on the demand for sugar, SSBs and foods high in fat, sugar or salt (HFSS) in India while exploring its impact on tax revenues. PE of sugar was estimated using Private Final Consumption Expenditure and Consumer Price Index data while price elasticities for SSBs and HFSS were obtained from literature. The reduction in demand was estimated for an additional 10-30% HT added to the current goods and services tax, for varying levels of price elasticities. The results show that for manufacturers of sweets and confectionaries who buy sugar in bulk and assuming a higher price elasticity of -0.70, 20% additional HT (total tax 48%) would result in 13-18% decrease in the demand for sugar used for confectionaries and sweets. For SSBs, HT of 10-30% would result in 7-30% decline in the demand of SSBs. For HFSS food products, 10-30% HT would result in 5-24% decline in the demand for HFSS products. These additional taxes would increase tax revenues for the government by 12-200% across different scenarios. Taxing unhealthy foods is likely to reduce demand, while increasing government revenues for reinvestment back into public health programmes and policies that may reduce obesity and the incidence of non-communicable diseases in India.

Development of fish snack (Keropok) with sodium reduction using alternative salts (KCl and CaCl2)

The incidence of non-communicable diseases (NCDs) caused by excessive sodium intake is becoming an important issue that many researchers have investigated. Processing is an effective way to add value to underutilized fish species. Thus, the objective of this research was to develop a fish snack (Keropok) using reduced sodium. Two types of alternative sodium chloride (NaCl) were used, namely potassium chloride (KCl) and calcium chloride (CaCl2) with substitution at levels of 15, 30, and 45 % (w/w). The results indicated that substitution of NaCl with KCl or CaCl2 in the product had a negative effect on the cooking yield (%) (P<0.05). Using 55 % NaCl with 45 % KCl (B3) in Keropok had a consumer acceptance score similar to the control formula (P>0.05) and the lowest sodium content (P<0.05). After storage at 4 °C for 21 days, the microbial loads (Bacillus cereus, Escherichia coli, mold, Staphylococcus aureus, yeast) in B3 satisfied the requirements of the Thailand Community Product Standard (107/2011). In addition, increasing the storage time did not affect the texture of the product (hardness, gumminess, chewiness and cohesiveness) nor consumer acceptance (P>0.05). B3 was rich in nutrients (macromolecules and micromolecules) that are essential to the human body. Therefore, Kerepok (55 % NaCl with 45 % KCl: B3) could be considered as a healthy snack.

Analysis of risky food consumption behavior among university students

Non-communicable diseases (NCD) and oral disease problems can arise in all age groups, including teenagers. Risky behavior is caused by a poor lifestyle and other factors. This study aimed to determine risky behavior and NCD incidence as well as oral problems in students at the Yogyakarta campus. This can lead NCD and oral problems. This research is quantitative descriptive-analytic research condected in a private university in Yogyakarta. The data was collected through an electronic questionnaire (Google form) and analyzed descriptively. Among the students' risky behaviors, 87.27% consumed excessive sweet food, 87.88% salty food, 82.42% oily food, 80% of seasonings, 57.58% consumed instant noodles, 84.85% consumed too little fruit and vegetables, and 87.27% did not participate in physical activity for 30 minutes. In the last 12 months, there was a high incidence of dental and oral health issues among students without symptoms. It was concluded that the most dominant risk behavior for non- communicable disease correlated with poor diet related to food consumption and lack of physical activity. All students had no symptoms or no doctor's diagnosis, but students experienced oral health problem within 12 months. A healthy diet, regular exercise, and good oral hygiene can reduce the risk of NCDs and dental and oral diseases.

Salivary proteomic profile of young healthy subjects

Background: The incidence of noncommunicable diseases (NCDs) has been rapidly ramped up worldwide. Hence, there is an urgent need to non-invasively detect NCDs possibly by exploiting saliva as a ‘liquid biopsy’ to identify biomarkers of the health status. Since, the absence of standardized procedures of collection/analysis and the lack of normal ranges makes the use of saliva still tricky, our purpose was to outline a salivary proteomic profile which features healthy individuals.Methods: We collected saliva samples from 19 young blood donors as reference population and the proteomic profile was investigated through mass-spectrometry.Results: We identified 1,004 proteins of whose 243 proteins were shared by all subjects. By applying a data clustering approach, we found a set of six most representative proteins across all subjects including Coronin-1A, F-actin-capping protein subunit alpha, Immunoglobulin J chain, Prosaposin, 78 kDa glucose-regulated protein and Heat shock 70 kDa protein 1A and 1B.Conclusion: All of these proteins are involved in immune system activation, cellular stress responses, proliferation, and invasion thus suggesting their use as biomarkers in patients with NCDs.

Unravelling the determinants of human health in French Polynesia: the MATAEA project.

French Polynesia is a French overseas collectivity in the Southeast Pacific, comprising 75 inhabited islands across five archipelagoes. The human settlement of the region corresponds to the last massive migration of humans to empty territories, but its timeline is still debated. Despite their recent population history and geographical isolation, inhabitants of French Polynesia experience health issues similar to those of continental countries. Modern lifestyles and increased longevity have led to a rise in non-communicable diseases (NCDs) such as obesity, diabetes, hypertension, and cardiovascular diseases. Likewise, international trade and people mobility have caused the emergence of communicable diseases (CDs) including mosquito-borne and respiratory diseases. Additionally, chronic pathologies including acute rheumatic fever, liver diseases, and ciguatera, are highly prevalent in French Polynesia. However, data on such diseases are scarce and not representative of the geographic fragmentation of the population. The present project aims to estimate the prevalence of several NCDs and CDs in the population of the five archipelagoes, and identify associated risk factors. Moreover, genetic analyses will contribute to determine the sequence and timings of the peopling history of French Polynesia, and identify causal links between past genetic adaptation to island environments, and present-day susceptibility to certain diseases. This cross-sectional survey is based on the random selection of 2,100 adults aged 18-69 years and residing on 18 islands from the five archipelagoes. Each participant answered a questionnaire on a wide range of topics (including demographic characteristics, lifestyle habits and medical history), underwent physical measurements (height, weight, waist circumference, arterial pressure, and skin pigmentation), and provided biological samples (blood, saliva, and stool) for biological, genetic and microbiological analyses. For the first time in French Polynesia, the present project allows to collect a wide range of data to explore the existence of indicators and/or risk factors for multiple pathologies of public health concern. The results will help health authorities to adapt actions and preventive measures aimed at reducing the incidence of NCDs and CDs. Moreover, the new genomic data generated in this study, combined with anthropological data, will increase our understanding of the peopling history of French Polynesia. https://clinicaltrials.gov/, identifier: NCT06133400.

2958. Investigating the mechanisms of persistent inflammation and the association with non-communicable diseases (NCDs), Tuberculosis (TB) recurrence, and other infections

Abstract Background TB continues to be a major cause of morbidity and mortality worldwide. Despite successful completion of anti-tuberculosis therapy (ATT), studies indicate that TB survivors (post-TB) have a significantly higher risk of mortality compared to the general population, primarily due to increased incidence of non-communicable diseases (NCDs; cardiovascular disease, cancer, lung disease) and recurrent infections. Furthermore, a considerable proportion of TB patients exhibit persistent inflammation even after ATT. Methods We enrolled 325 individuals with microbiologically confirmed pulmonary TB, diagnosed between 2014 and 2020. Blood samples were obtained at baseline and 12- months (6-months after completing antimicrobial therapy) to evaluate persistent inflammation. Plasma C-reactive protein (CRP) was used to measure inflammation. Lipid peroxidation (LP) was measured by oxidized (HNE) LDL. Redox capacity was measured via the Trolox assay. Immune activation was measured by the Indoleamine 2,3 dioxygenases (IDO) enzyme by measuring the Kynurenine-Tryptophan ratio. Results After successful TB treatment, 62% of participants exhibited persistent elevation of CRP (P&amp;lt; 0.001) (Figure 1a). Univariate analysis of the first 186 participants revealed no association between elevated post-TB inflammation and HIV status (Fig. 1B), gender, or age. Individuals with increased CRP levels had a lower redox capacity compared to those whose CRP normalized at the end of ATT (P&amp;lt; 0.001) (Figure 2). Analysis of Oxidized LDL in successfully treated TB patients demonstrated that low antioxidant capacity also had persistent LP (Figure 2b). IDO activity was increased among TB participants with high CRP, which persisted even after successful therapy in participants with high and low CRP levels (Figure 3). Fig 1a: CRP was evaluated on TB participants and their asymptomatic, healthy household contacts. The median CRP of the healthy contacts was &amp;lt;2 mg/L, whereas the median CRP for TB participants at baseline was 21 and decreased to 8 at the end of successful therapy (EOT). Previous studies have demonstrated that CRP levels &amp;gt;3 mg/L are associated with increased CVD risk . 62% (111/186) of TB participants have CRP levels &amp;gt;3 mg//L at the end of TB therapy. Fig 1b: All TB participants living with HIV (PLWH) are started on ART, with &amp;gt;90% having a viral load &amp;lt;1000 at end of therapy (EOT). At EOT, TB participants without HIV do not have lower CRP levels compared to PLWHIV, preliminarily suggesting HIV is not driving the persistent inflammation. Fig2a: The Trolox antioxidant capacity was evaluated on TB Participants with High CRP &amp;gt;3mg/L (n:36) vs Low CRP &amp;lt;3mg/L (n:32) and Healthy Controls (n:32). Conclusion This study shows that a substantial proportion of TB participants exhibit persistent inflammation and IDO activity even after ATT. Among TB participants who do not normalize inflammation at the end of successful therapy, there is also persistent LP and decreased redox capacity. This suggests that there is a bidirectional malignant relationship between LP and redox capacity. Potentially, this suggests that mitigating lipid peroxidation may help decrease post-TB inflammation. Fig2b: Oxidized LDL was measured in TB individuals with High levels of CRP High CRP &amp;gt;3mg/L (n:16) vs Low CRP &amp;lt;3mg/L (n:16) and Healthy Controls (n:4) Fig3 Plasma Kynurenine to Tryptophan ratio was evaluated in TB individuals with persistent augmented levels of CRP (n:19) at baseline and Heathy Controls. At the end of Therapy the KYN:TRYP was evaluated in TB individuals with high (n:22) and Low CRP levels (n:17) Disclosures All Authors: No reported disclosures

Exploring the common millets of India: A comprehensive review

Millets were a part of human diet as well as fodder in the past and was helpful in prevention of many diseases especially lifestyle diseases. Because of the dependence on wheat and rice as major source of food and the rise in use of junk food, millets were neglected from routine diet. The rise in incidence of non-communicable diseases, across the globe has helped generate an awareness to include nutri-cereals in the daily food to address the contemporary of lifestyle. Information pertaining to millets, especially on Indian millets, has been collected from various resources, books, research papers and e-platforms for the researches on millets. Nine types of millets are widely used across India. Millets have been the cornerstone of Indian cuisine since centuries and there is much scope for its revival in the present era.